Skip to main content
. Author manuscript; available in PMC: 2018 Dec 4.
Published in final edited form as: Nat Mater. 2018 Jun 4;17(8):732–739. doi: 10.1038/s41563-018-0099-0

Figure 5. Treg cells are required for islet graft acceptance.

Figure 5

Depletion of Treg cells results in acute rejection of established islet grafts. C57BL/6.FoxP3EGFP/DTR mice were transplanted with BALB/c islets and SA-FasL-presenting microgels under transient cover of rapamycin (administered i.p. daily at 0.2 mg/kg for 15 doses). A cohort of mice (n=5) was injected i.p. with 50 µg/kg diphtheria toxin on day 50 post-transplantation (arrow) to deplete Treg cells, while another group (n=4) was left untreated. Data comprise transplants performed from various islet isolations with sample size indicating number of treated mice. Survival curves post day 50 were analyzed using Mantel-Cox test (χ2 = 6.26, df = 1, p < 0.0123).