Fig 1.

Individual biopsies from areas of intact and disrupted vascular function exhibit distinct histopathologic characteristics. A, Biopsy locations overlaid onto T1 postcontrast, FLAIR, and BOLD images with correlative histopathology in B and C. The sample from relatively normal BOLD signal, representing normal vascular function (orange, B), shows normal cellularity and high NeuN staining, suggestive of noninfiltrated gray matter, whereas the sample from a region of BOLD signal abnormality (green, C) shows tumor tissue and no neuronal staining.