Table 2.
Loci disrupted in bile-sensitive mutants and the functions of gene products.
| Genes disrupted in bile-sensitive mutants | Function of gene products/putative function | Reference(s) |
|---|---|---|
| Gram-negative bacteria | ||
| Klebsiella | ||
| marA | Multiple antibiotic resistance protein – Regulatory genes | 11,19,20 |
| marB | Multiple antibiotic resistance protein – Regulatory genes | 11,19,20 |
| marC | Multiple antibiotic resistance protein – Regulatory genes | 11,19,20 |
| marR | Regulatory genes | 11,19,20 |
| TolC precursor | Efflux pump function | 17,21 |
| dam | DNA adenine methylase | 24 |
| emrE | Efflux pump –drug resistance | 31 |
| emrB | Efflux pump – drug resistance | 31 |
| mdtABCD | Efflux pump –multi drug resistance | 22,31 |
| cmeA | Efflux pump | 23,31 |
| cmeB | Efflux pump | 23,31 |
| sbcC | Exonuclease | 25 |
| MutS | DNA mismatch repair | 25 |
| nifJ homolog | Pyruvate flavodoxin oxidoreductase | 25 |
| yvaG | 3-oxoacyl-acyl-carrier protein reductase | 25 |
| dgt homolog | Deoxyguanosinetriphosphate triphosphohydrolase | 25 |
| Escherichia | ||
| yvaG | 3-oxoacyl-acyl-carrier protein reductase | 25 |
| Shigella | ||
| PhoQ | Regulatory genes | 34 |
| Gram-positive bacteria | ||
| Enterococcus | ||
| emrB | Efflux pump – drug resistance | 31 |
| sbcC homolog | Exonuclease | 25 |
| MutS | DNA mismatch repair | 25 |
| nifJ homolog | Pyruvate-flavodoxin oxidoreductase | 25 |
| yvaG | 3-oxoacyl-acyl-carrier protein reductase | 25 |
| dgt homolog | Deoxyguanosinetriphosphate triphosphohydrolase | 25 |