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. 2018 Jul 25;9:2909. doi: 10.1038/s41467-018-05244-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Soluble RANKL contributes to osteoclast formation in adult mice. a sRANKL levels in the blood plasma of 5-week-old Tnfsf11^+/+ (n = 8), Tnfsf11^SR/SR (n = 9), and Tnfsr11^−/− (n = 2) mice. ND not detectable. b X-ray images from 5-week-old Tnfsf11^+/+, Tnfsf11^SR/SR, and Tnfsr11^−/− mice. Arrowheads indicate position of lower incisors. c Cancellous bone volume of L4 vertebra from 5-week-old Tnfsf11^+/+ (n = 8), Tnfsf11^SR/SR (n = 9), and Tnfsr11^−/− (n = 4) mice. *P < 0.05 versus Tnfsf11^+/+ or Tnfsf11^SR/SR mice using one-way ANOVA. d Cortical thickness of femurs from 5-week-old Tnfsf11^+/+ (n = 8) and Tnfsf11^SR/SR (n = 9) mice. e Cancellous bone volume of L4 vertebra from 3-month-old female Tnfsf11^+/+ (n = 9) and Tnfsf11^SR/SR (n = 13) and male Tnfsf11^+/+ (n = 8) and Tnfsf11^SR/SR (n = 9) mice and 8-month-old female Tnfsf11^+/+ (n = 5) and Tnfsf11^SR/SR (n = 4) and male Tnfsf11^+/+ (n = 9) and Tnfsf11^SR/SR (n = 10) mice. *P < 0.05 versus Tnfsf11^+/+ mice using Student’s t test. f Osteoclast number per mm bone surface measured in the cancellous bone of L1–L3 vertebra of 3-month-old Tnfsf11^+/+ (n = 6) and Tnfsf11^SR/SR (n = 6), and 8-month-old Tnfsf11^+/+ (n = 5) and Tnfsf11^SR/SR (n = 4), female littermates. *P < 0.05 using Student’s t test. g Cortical thickness of femurs from 3-month-old female Tnfsf11^+/+ (n = 9) and Tnfsf11^SR/SR (n = 13) and male Tnfsf11^+/+ (n = 9) and Tnfsf11^SR/SR (n = 9) mice and 8-month-old female Tnfsf11^+/+ (n = 5) and Tnfsf11^SR/SR (n = 4) and male Tnfsf11^+/+ (n = 9) and Tnfsf11^SR/SR (n = 10) mice. All analyses of 5-week-old mice included both sexes. All values are means ± s.d.