Figure 3.

An example of the output page of the query “kakkonto” (an example of Kampo medicines) as an input in the “Natural medicines list” component. The 1st layer shows the Kampo medicine query (“kakkonto” in this case). The 2nd layer shows the crude drugs (e.g., “Ephedra herb”) that form the Kampo medicine (“kakkonto” in this case). The 3rd layer shows the constituent compounds (e.g., “Methylephedrine”) that form the crude drug (“Ephedra herb” in this case). The 4th layer shows the target proteins (e.g., “ADRA1D”) that are known to interact with the constituent compound (“Methylephedrine” in this case).