Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 25;8:11185. doi: 10.1038/s41598-018-29078-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Involvement of residues at position 64 and 71 of HCV core in the modulation of TCF-element activation. (a) HCV core is schematically represented with its subdomains (D1, D2, D3) including predicted or experimentally-demonstrated nuclear localization signals (NLS), nuclear export signals (NES), alpha-helices (H), loop between alpha-helices (HL), and location of cleavage by cellular signal peptidase (SP) and signal peptide peptidase (SPP) (scissors). Numbering below the scheme corresponds to amino acid position framing each element in core. An alignment of core sequences from clinical isolates and engineered mutant derivatives 1aH77 P64S and 4aR S71T is shown in the blown-up below. Amino acid differences are boxed. (b,c) Relative TCF element activation in HEK293 cells expressing natural or engineered core variants and statistical analyses were established and represented as described in Fig. 1 caption (means ± SD of quintuplicates obtained in 3 independent experiments).