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. 2018 Jul 25;8:11185. doi: 10.1038/s41598-018-29078-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Strain-specific, core-dependent nuclear translocation of β-catenin in infected cells. (a) Huh-7.5 cells infected with the indicated viruses or noninfected cells were labeled for nucleus (DAPI, blue) and core (green), as well as for β-catenin (yellow). Merged deconvolved images and representative 3D segments used for object segmentation (nuclei and β-catenin, right images) are shown. (b) Images were subjected to object analysis (co-localization intersection) using Huygens Professional software and intersecting volumes between β-catenin and nucleus were quantified per cell. Intersecting voxels (means and distribution among 23 cells per condition, each cell being represented by a symbol) were expressed relatively to intersecting voxels found in noninfected cells set at 1. Statistical analyses with respect to values obtained in noninfected cells are indicated above each group of virus-infected cells (in grey characters), while statistical analyses between two related variants are indicated in black characters above brackets. These statistical analyses were performed according to the Holm-Sidak method and are coded as follows: P < 0.05 (*), P < 0.005 (**), P < 0.001 (***).