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. 2018 Jul 25;8:11227. doi: 10.1038/s41598-018-29072-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Telomere length distribution in control, HNCM and HOCM. (A) Relative leukocyte telomere length expressed as the log-transformed ratio of the telomeric sequence to single reference gene (T/S), plotted as a function of age. The negative slopes of the linear regression lines indicate age-related telomere shortening. (B) Average log-transformed T/S ratio in control subjects versus HNCM and HOCM patients. The results are shown as mean ± SD. Between-group differences were analyzed using one-way ANOVA, followed by Tukey’s post hoc test. **P < 0.010.