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. 2018 Jul 25;8:11198. doi: 10.1038/s41598-018-29558-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Elevated IL-10 and HO-1 are associated with severity of sepsis. Correlations for the relationship between APACHE II score and (A) Haemoglobin (Hb), (B) haptoglobin (HPT), (C) haem, (D) haemopexin (HPX), (E) IL-10, and (F) HO-1. Correlations for the relationship between SOFA score and (G) IL-10, and (H) HO-1. Log-transformed data shown with linear regression line. Pearson r and p-value shown. Kaplan–Meier survival curves with hazard ratio comparing individuals above the median to those below the median for (I) IL-10 (median 117.89 ng/mL), (J) HO-1 (median 23.105 ng/mL), and (K) haem (median 21.075 uM).