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. 2018 Jul 25;9:2905. doi: 10.1038/s41467-018-05328-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — hQTLs impact gene expression in haplotype blocks that also contain eQTLs. Figure plots the 87 haplotypes for which the hQTL demonstrated significantly increased ability to model expression variation of the eQTL target gene (p_permutation < 0.05). The proportion of additional gene expression variation by incorporation of the hQTL genotypes (D²) is plotted on the y-axis and the permutation p-value is plotted on the x-axis. HLA haplotypes are colored in red and non-HLA haplotypes are in black