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. 2018 Jul 25;8:11192. doi: 10.1038/s41598-018-29229-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Community-wide microbiota composition profiling of the top 20 taxa down to the family level detected by 16S rRNA gene amplicon (V4 region) sequencing. The microbiota profiles in all 4 visits for both probiotic and placebo supplement represent the average relative microbiota composition abundance of all 35 participants in each visit of both arms of the study.