Figure 5. β-Catenin signaling were decreased in Cbs^−/− dental pulp.

a Cbs^−/− mice dental pulp showed more cells than control ones. b The average dentin thickness of mandible first molar is less in Cbs^−/− mice than control ones, as assessed by micro-CT. c DSPP⁺ cells decreased in Cbs^−/− mice dental pulp compared to control ones. d PCNA⁺ cells increased in Cbs^−/− mice dental pulp. e, f p-GSK3β⁺ and active-β-catenin cells decreased in Cbs^−/− mice dental pulp. *P < 0.05, **P < 0.01, ***P < 0.001,   scale bar: 200 μm left panel, 100 μm right panel (a), 1 mm (b), 20 μm (c–f). All experimental data were verified in at least three independent experiments