Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 25;8:11191. doi: 10.1038/s41598-018-29352-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Nucleus pulposus-specific stabilization of b-Catenin increased the compressive stiffness of tail and lumbar discs. (A) Experimental design/timeline of 4 mo bCAT cACT mice and harvest after 1 mo. Red “X’s” indicate tissue harvest. Letters on the right side of the “X’s” indicate the panels in the timeline. (B,D,F) Are in tail IVD and (C,E and G) are in lumbar IVD. tdTomato reporter of the expression of Shh was (B) throughout the NP of the tail IVD and cartilage endplate (white arrows), but (C) Shh expression was 34% of the cells in the lumbar NP (white arrow, n = 3). Safranin-O stain of bCAT cACT and WT of (D) tails and (E) lumbar IVD (white arrows indicate proteoglycan nodules). Mechanical properties (Compression, Tension, Neutral Zone) of (F) tail (n = 5–8) and (G) lumbar IVDs (n = 5–6). Scale bar: (B–E) 100 µm. Data are presented as mean + SD. bCAT cACT vs. WT; *p < 0.05.