Table 1.
Comparison of physiological, hematological and biochemical parameters between sea level and 3700 m (N = 318)
| Measurements at sea-level | Measurements at 3700 m | p | |
|---|---|---|---|
| Demographic data | |||
| Age, y | 21.87 ± 3.33 | the same as sea-level | – |
| BMI, kg/m2 | 22.06 ± 1.99 | the same as sea-level | – |
| chest circumstance, cm | 86.11 ± 5.09 | the same as sea-level | – |
| Smoking, yes(%) | 102 (32.1) | the same as sea-level | – |
| Drinking, yes(%) | 39 (12.3) | the same as sea-level | – |
| Physical parameters | |||
| SpO2, % | 98.00 (98.00–98.20) | 88.00 (85.10–90.20) | < 0.001** |
| HR, beats/min | 67.49 ± 9.18 | 84.17 ± 12.15 | < 0.001** |
| SBP, mmHg | 111.22 ± 9.81 | 120.52 ± 12.8 | < 0.001** |
| DBP, mmHg | 71.85 ± 8.14 | 81.77 ± 9.56 | < 0.001** |
| Hematological parameters | |||
| RBC, *1012 | 5.00 (4.80–5.20) | 5.11 (4.82–5.49) | < 0.001** |
| Hgb, g/L | 151.10 (144.00–157.00) | 157.00 (147.00–169.30) | < 0.001** |
| Hct, % | 44.49 ± 3.10 | 48.42 ± 6.08 | < 0.001** |
| MCV, fL | 92.20 (90.00–94.22) | 86.50 (84.40–88.62) | < 0.001** |
| MCH, pg | 30.59 (29.61–31.30) | 30.90 (30.20–32.10) | < 0.001** |
| PLT, *109 | 206.79 ± 44.77 | 244.97 ± 69.80 | < 0.001** |
| MPV, fL | 10.50 (9.80–11.00) | 10.60 (10.20–11.00) | 0.006** |
| WBC, *109 | 6.10 (5.40–7.10) | 7.90 (7.00–9.50) | < 0.001** |
| LYM%, % | 36.23 ± 7.59 | 36.49 ± 9.06 | 0.833 |
| LYM#, *109 | 2.20 (1.90–2.60) | 2.95 (2.50–3.40) | < 0.001** |
| Biochemical parameters | |||
| ALT, U/L | 18.00 (15.00–23.00) | 39.20 (30.40–48.50) | < 0.001** |
| AST, U/L | 15.10 (12.30–18.50) | 31.00 (25.50–40.60) | < 0.001** |
| BUN, mmol/L | 4.45 (3.89–5.28) | 4.60 (4.10–5.25) | 0.109 |
| CREA, umol/L | 58.00 (49.00–68.10) | 105.40 (98.60–114.00) | < 0.001** |
| TBIL, umol/L | 12.60 (10.80–14.00) | 12.30 (10.20–15.65) | 0.023* |
| DBIL, umol/L | 3.10 (2.30–3.50) | 4.70 (3.90–5.80) | < 0.001** |
| IBIL, umol/L | 9.70 (8.50–10.50) | 7.70 (5.80–10.65) | < 0.001** |
SpO2 blood oxygen saturation, HR heart rate at resting, SBP systolic blood pressure, DBP diastolic blood pressure, RBC red blood cell count, Hgb hemoglobin, Hct hematocrit, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, PLT platelets count, MPV mean platelet volume, WBC white blood cell, LYM% lymphocyte rate, LYM# lymphocyte count, ALT alanine aminotransferase, AST aspartate aminotransferase, BUN blood urea nitrogen, CREA creatinine, TBIL total serum bilirubin, DBIL direct serum bilirubin, IBIL indirect serum bilirubin
Normally distributed variables were presented as mean ± SD, and compared using paired-sample T test; Non-normally distributed variables were presented as mean (interquartile range), and compared using Mann-Whitney U test
*p value indicates p < 0.05; **p value indicates p < 0.01