Table 3.

Cox regression models (with hazard ratios (HRs) and 95% confidence interval (CI)) for incident hospital diagnosis of dementia among patients aged ≥ 45 years with diagnoses of AF (n = 11,063) in primary care attending the 75 PHCCs between January 1, 2001 and December 31, 2007; patients with an earlier known hospital episode of dementia before AF diagnosis excluded

	Men (n = 6216)		Women (n = 4847)
	Model 1	Model 2	Model 1	Model 2
Diagnosis
Hypertension	0.98 (0.78–1.24)	0.95 (0.75–1.21)	0.78 (0.63–0.96)	0.77 (0.62–0.95)
Myocardial infarction	0.87 (0.61–1.24)	0.92 (0.64–1.33)	0.51 (0.34–0.77)	0.52 (0.35–0.79)
Congestive heart failure	0.71 (0.55–0.90)	0.71 (0.56–0.91)	0.65 (0.53–0.81)	0.68 (0.55–0.85)
Cerebrovascular diseases	1.02 (0.77–1.36)	0.98 (0.73–1.31)	0.75 (0.57–0.98)	0.69 (0.52–0.91)
Ischemic stroke	1.08 (0.81–1.45)	–	0.75 (0.57–0.99)	–
Bleeding stroke	0.60 (0.22–1.62)	–	0.75 (0.28–2.02)	–
Obesity	0.58 (0.24–1.43)	0.54 (0.22–1.32)	0.64 (0.30–1.35)	0.62 (0.29–1.34)
Diabetes mellitus	1.40 (1.08–1.83)	1.50 (1.15–1.96)	1.07 (0.83–1.39)	1.20 (0.92–1.56)
COPD	0.77 (0.52–1.15)	0.80 (0.54–1.20)	1.24 (0.93–1.67)	1.28 (0.95–1.72)
Depression	1.67 (1.14–2.44)	1.54 (1.04–2.28)	1.18 (0.87–1.61)	1.16 (0.85–1.59)
Anxiety	1.56 (0.87–2.78)	1.46 (0.80–2.65)	1.24 (0.82–1.88)	1.23 (0.80–1.88)
Anticoagulant treatment	–	0.78 (0.61–0.98)	–	0.81 (0.65–0.99)

Model 1 is for each comorbidity separately and adjusted for age and sociodemographic variables (educational level, marital status, and neighborhood socioeconomic status). Model 2 is multivariate with adjustment as in model 1 but also for all comorbidities (hypertension, myocardial infarction, congestive heart failure, cerebrovascular diseases, obesity, diabetes, COPD, depression, and anxiety) and anticoagulant treatment. Significant interaction was found between age and marital status. Italicized values are statistically significant