Table 3.
Effective connectivity strengths in patients and controls
| Regions of interest | Within groups | Between groups | ||||
|---|---|---|---|---|---|---|
| DOC | HC | DOC-HC | ||||
| Mean ± SD | P-value | Mean ± SD | P-value | Mean differences | P-value | |
| From mPFC to | ||||||
| mPFC | − 0.35 ± 0.38* | 0.001 | − 0.55 ± 0.41* | 0.000 | 0.20 | 0.065 |
| PCC | − 0.08 ± 0.54 | 0.555 | 0.09 ± 0.27 | 0.152 | − 0.17 | 0.126 |
| Thalamus | 0.01 ± 0.33 | 0.900 | 0.12 ± 0.82 | 0.536 | − 0.11 | 0.299 |
| Striatum | − 0.17 ± 0.49 | 0.157 | − 0.13 ± 0.79 | 0.489 | 0.04 | 0.435 |
| Globus pallidus | − 0.09 ± 0.54 | 0.467 | − 0.13 ± 0.67 | 0.399 | 0.04 | 0.424 |
| From PCC to | ||||||
| mPFC | 0.24 ± 0.44 | 0.028 | 0.02 ± 0.29 | 0.753 | 0.22 | 0.041 |
| PCC | − 0.54 ± 0.34* | 0.000 | − 0.53 ± 0.28* | 0.000 | − 0.01 | 0.450 |
| Thalamus | − 0.06 ± 0.19 | 0.225 | 0.10 ± 0.65 | 0.503 | − 0.16 | 0.165 |
| Striatum | − 0.10 ± 0.41 | 0.324 | − 0.21 ± 0.54 | 0.101 | 0.12 | 0.228 |
| Globus pallidus | 0.22 ± 0.68 | 0.180 | − 0.57 ± 0.61* | 0.001 | 0.79# | 0.001 |
| From thalamus to | ||||||
| mPFC | − 0.03 ± 0.34 | 0.686 | 0.01 ± 0.07 | 0.597 | − 0.04 | 0.324 |
| PCC | − 0.02 ± 0.45 | 0.877 | 0.00 ± 0.11 | 0.909 | − 0.01 | 0.455 |
| Thalamus | − 0.50 ± 0.26* | 0.000 | − 0.45 ± 0.25* | 0.000 | − 0.05 | 0.277 |
| Striatum | 0.08 ± 0.64 | 0.599 | − 0.03 ± 0.45 | 0.794 | 0.11 | 0.279 |
| Globus pallidus | − 0.17 ± 0.70 | 0.317 | 0.26 ± 0.32 | 0.002 | − 0.43 | 0.011 |
| From striatum to | ||||||
| mPFC | − 0.10 ± 0.30 | 0.164 | 0.06 ± 0.15 | 0.091 | − 0.16 | 0.020 |
| PCC | − 0.03 ± 0.28 | 0.612 | 0.01 ± 0.14 | 0.873 | − 0.04 | 0.305 |
| Thalamus | 0.04 ± 0.43 | 0.652 | − 0.13 ± 0.26 | 0.037 | 0.17 | 0.064 |
| Striatum | − 0.40 ± 0.39* | 0.000 | − 0.46 ± 0.32* | 0.000 | 0.06 | 0.304 |
| Globus pallidus | − 0.23 ± 0.60 | 0.113 | 0.25 ± 0.54 | 0.054 | − 0.48# | 0.006 |
| From globus pallidus to | ||||||
| mPFC | 0.03 ± 0.30 | 0.623 | 0.02 ± 0.18 | 0.691 | 0.02 | 0.418 |
| PCC | − 0.12 ± 0.33 | 0.131 | 0.04 ± 0.17 | 0.310 | − 0.16 | 0.032 |
| Thalamus | 0.06 ± 0.28 | 0.389 | − 0.28 ± 0.33 | 0.002 | 0.34# | 0.001 |
| Striatum | 0.31 ± 0.32* | 0.001 | 0.11 ± 0.37 | 0.201 | 0.20 | 0.039 |
| Globus pallidus | − 0.22 ± 0.25 | 0.001 | − 0.40 ± 0.39* | 0.000 | 0.18 | 0.042 |
*Significant effective connectivity at the group level (P < 0.05, FDR-corrected); #significant differences between groups (P < 0.05, FDR-corrected); significant differences (P < 0.04, uncorrected) between groups are shown in bold. PCC, posterior cingulate cortex; mPFC, medial prefrontal cortex