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. 2018 Jul 19;9:1639. doi: 10.3389/fimmu.2018.01639

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Copyright © 2018 Kholia, Herrera Sanchez, Cedrino, Papadimitriou, Tapparo, Deregibus, Brizzi, Tetta and Camussi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human liver stem cell-derived extracellular vesicles (HLSC-EVs) downregulate pro-fibrotic genes in mice treated with aristolochic acid (AA). Gene expression levels of α-Sma (A), Col1a1 (B), Tgfb1 (C), and Ltbp1 (D) in mice treated with vehicle alone (control), mice treated with AA, AA mice treated with HLSC-EVs or Fibro-EVs. Data show mean ± SD of n = 7 mice per treatment. ***p < 0.001 AA vs control, *p < 0.05, **p < 0.01, ***p < 0.001 HLSC-EVs vs AA. No significant differences were observed between AA vs Fibro-EVs.