Table 3.
Regulation of pro-fibrotic genes in AA mice and AA mice treated with HLSC-EVs.
| Genes upregulated in AA mice | Genes downregulated in HLSC-EV mice | |
|---|---|---|
| Acta2 | Mmp14 | Ccl12 |
| Cav1 | Mmp2 | Ccr2 |
| Ccl11 | Mmp3 | Egf |
| Ccl12 | Mmp8 | Fasl |
| Ccl3 | Mmp9 | Ifng |
| Ccr2 | Myc | Il13 |
| Col1a2 | Plat | Il13ra2 |
| Col3a1 | Serpina1a | Inhbe |
| Dcn | Serpine1 | Ltbp1 |
| Edn1 | Snai1 | Plg |
| Grem1 | Tgfb1 | Serpina1a |
| Hgf | Tgfb2 | Smad6 |
| Il1b | Thbs1 | Snai1 |
| Itga2 | Thbs2 | Stat1 |
| Itga3 | Timp1 | |
| Jun | Timp2 | |
| Lox | Tnf | |
| Ltbp1 | ||
Thirty five genes were upregulated in mice treated with aristolochic acid (AA). Fourteen genes were downregulated in AA mice treated with human liver stem cell-derived extracellular vesicles (HLSC-EVs). Five genes were common between the two lists (highlighted in red).