Table 3.
Genes upregulated in AA mice | Genes downregulated in HLSC-EV mice | |
---|---|---|
Acta2 | Mmp14 | Ccl12 |
Cav1 | Mmp2 | Ccr2 |
Ccl11 | Mmp3 | Egf |
Ccl12 | Mmp8 | Fasl |
Ccl3 | Mmp9 | Ifng |
Ccr2 | Myc | Il13 |
Col1a2 | Plat | Il13ra2 |
Col3a1 | Serpina1a | Inhbe |
Dcn | Serpine1 | Ltbp1 |
Edn1 | Snai1 | Plg |
Grem1 | Tgfb1 | Serpina1a |
Hgf | Tgfb2 | Smad6 |
Il1b | Thbs1 | Snai1 |
Itga2 | Thbs2 | Stat1 |
Itga3 | Timp1 | |
Jun | Timp2 | |
Lox | Tnf | |
Ltbp1 |
Thirty five genes were upregulated in mice treated with aristolochic acid (AA). Fourteen genes were downregulated in AA mice treated with human liver stem cell-derived extracellular vesicles (HLSC-EVs). Five genes were common between the two lists (highlighted in red).