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. 2018 Jul 19;5:164. doi: 10.3389/fvets.2018.00164

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Copyright © 2018 Lossi and Merighi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Use of OCs in the study of axon regeneration and reconstruction of circuitries. (A) Assessment of drug neuroprotective activity on axotomized neurons in OCs; (B) Co-culture of two brain slices. One of the two slices (OC1–source) contains the parent cell bodies of the axons connected with the other slice (OC2–target). These connections are intentionally cut in the preparation of the explant and axonal regeneration is followed in OC2 under control conditions (spontaneous re-innervation) or after pharmacological treatments. In the example, neurons in OC1 are made fluorescent by genetic engineering so that their axons can be easily traced in OC2.