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. 2018 Jul 25;25(1):1585–1594. doi: 10.1080/10717544.2018.1492046

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Pharmacokinetic and biodistribution profile of voriconazole from two different formulations. (A) Blood levels of intravenously injected voriconazole versus time 0–24 h (AUC_0–24) delivered from liposomal formulation (circles) and VFEND^® (squares) at 10 mg/kg. (B) Concentrations versus time of the metabolite (voriconazole-N-oxide) measured within the hour following intravenous administration of the formulations. Data are expressed as mean ± SD (n = 12 animals per group). (C) Tissue distribution of voriconazole 4 h after I.V. administration of liposomal formulation (white bars) and voriconazole complexed in sulfobutyl ether-beta-cyclodextrin so + dium, commercially available as VFEND^® (black bars). Bars represent the standard deviation (n = 6). (*indicates p<.05).