Table 3. . Preferred therapy for management of typhoid fever.

Antimicrobial agents	Route of administration	Children	Adult
Ceftriaxone	IM/IV	50 mg/kg per day IV; for 7–10 days	1–2 g per day IV; for 7–10 days
Ciprofloxacin, levofloxacin or other FQ†	Oral/IV	–	FQ given in full doses as recommended; for 7–10 days
Azithromycin	Oral	Used in complicated cases	500 mg twice a day for 5 days
Cefixime–ofloxacin	Oral	–	200–200 mg; for 7–14 days

^†High-dose therapy is based on antimicrobial susceptibility profile of the infected typhoidal Salmonella strain, as majorities are nonsusceptible to quinolones. Least preferred as majority of the isolates show intermediate resistance to quinolones.

FQ: Fluoroquinolone; IM: Intramuscular; IV: Intravenous.