Figure 3.

Endothelial cell-expressed tetraspanins and co-expressed proteins relevant to leukocyte trafficking. Endothelial cells play critical roles in directing immune cells from the bloodstream into sites of inflammation or secondary lymphoid organs. Tetraspanins expressed in endothelial cells, including CD9, CD63, CD81, CD82, CD151, and Tspan5 and Tspan17, have been shown to impact on endothelial cell adhesive function, by regulating the function of various adhesion molecules (integrins, ICAM-1, VCAM-1, and P-selectin) and MMPs such as ADAM10.