Table 1.

Roles of tetraspanin family members in leukocyte–endothelial cell interactions, recruitment, and migration.

Tetraspanin	Immune cell expression	Impact on recruitment	Reference
CD9	Monocytes T cells Neutrophils Endothelial cells	Promotes cell motility through regulation of adhesion molecules, e.g., LFA-1 Promotes formation of endothelial adhesive platforms (EAPs)	(7, 58–61)
CD37	B cells Dendritic cells (DCs) Neutrophils	Promotes cell adhesion through regulation of integrins, e.g., α4β1, β2. Facilitates chemokine-directed migration Promotes cell spreading through regulation of integrin–cytoskeleton cross-talk, and/or integrin stability	(8, 62, 63)
CD63	Endothelial cells	Promotes leukocyte rolling on human umbilical vein endothelial cells through expression and clustering of P-selectin	(5)
CD81	NK cells B cells T cells Monocytes DCs Endothelial cells	Promotes cell adhesion through regulation of adhesion molecules, e.g., LFA-1, VLA-4 Promotes cell adhesion through regulation of actin-associated proteins, e.g., Rac1, Ezrin Required for DC migration	(10, 11, 64–68)
CD82	DCs T cells	Reduces cell motility through regulation of cytoskeletal proteins, e.g., RhoA Promotes cell adhesion through regulation of adhesion molecules, e.g., LFA-1, α4β1	(9, 69–72)
CD151	T cells Neutrophils Endothelial cells	Promotes cell migration through regulation of extracellular matrix binding Promotes cell adhesion through regulation of actin remodeling and formation of EAPs	(13, 14, 58, 59, 68)
Tspan5 and Tspan17 (TspanC8 family members)	Endothelial cells	Promote T cell transmigration via regulation of endothelial MMP ADAM10	(12)