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. 2018 Jul 18;12:216. doi: 10.3389/fncel.2018.00216

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Copyright © 2018 Piquet, Toussay, Hepp, Lerchundi, Le Douce, Faivre, Guiot, Bonvento and Cauli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic activity of layer II and III pyramidal cells. (A) Mean relative YFP/CFP ratio changes in pyramidal cells of non-Tg (black trace) and 3xTg-AD mice (red trace) induced by glucose (Glc) restriction (0.2 mM). Traces show mean (solid lines) ± standard errors of the mean (color shades). Note the slowly developing decrease in mean relative ratio during 0.2 mM Glucose superfusion. Note also the difference in the temporal profiles between non-Tg and 3xTg-AD mice. (B) Histograms show the metabolic activity (decrease in relative YFP/CFP ratio) at different time of glucose restriction. After 5 min of glucose restriction pyramidal cells of non-Tg mice exhibit a higher metabolic activity than those of 3xTg-AD mice. In contrast, during longer glucose restriction pyramidal cells of 3xTg-AD mice display a higher metabolic activity. n.s. not statistically significant.