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. 2018 Jul 18;12:216. doi: 10.3389/fncel.2018.00216

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Copyright © 2018 Piquet, Toussay, Hepp, Lerchundi, Le Douce, Faivre, Guiot, Bonvento and Cauli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of key molecular elements of glucose metabolism in layer II and III pyramidal cells. (A) Voltage responses (upper traces) induced by injection of current pulses (bottom traces) in a non-Tg layer II and III pyramidal cell. In response to just-above-threshold current pulse, this neuron fired an action potential with a long lasting biphasic AHP (middle trace). Near saturation it showed the typical firing of a regular spiking neuron with marked frequency adaptation and spike amplitude accommodation (shaded trace). (B) The pyramidal cell shown in (A) expressed vGluT1, GluT1, GluT3, HK1, pfkfb3, PFK1m, PFK1l, PFK1p, and G6PDx. (C) Histograms showing the expression profiles of key molecular elements of glucose metabolism in layer II and III pyramidal cells of non-Tg (black) and 3xTg-AD mice (red). No statistically significant difference in the occurrence of genes was observed. Note the very low occurrence of pfkfb3 and Gys1 (glycogen synthase) in pyramidal neurons.