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. 2018 Jul 19;9:960. doi: 10.3389/fphys.2018.00960

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Copyright © 2018 Ghayor and Weber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Percentage of bony bridging of the defect in relation to pore and bottleneck dimensions. In comparison to the empty control, scaffolds with pore diameters from 0.7 to 1.7 mm and bottlenecks below 1.5 mm perform significantly better. Scaffolds with pores of 1.2 mm and bottlenecks between 0.7 and 1.2 mm perform significantly better than scaffolds with a pore diameter of 1.5 mm and bottleneck of 1.2 mm and pore diameter of 1.7 mm and bottleneck of 0.7 mm. Results of each group are displayed as box-plots ranging from the 25th (lower quartile) to the 75th (upper quartile) percentile including the median as black bars and whiskers showing the minimum and maximum values. The number of samples for each group (N) is displayed on top of the figure.