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. 2018 Jul 19;9:1650. doi: 10.3389/fimmu.2018.01650

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Copyright © 2018 Vidyarthi, Khan, Agnihotri, Negi, Das, Aqdas, Chatterjee, Colegio, Tewari and Agrewala.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Administration of TLR-3L reverts the M2 phenotype of tumor-associated macrophages to M1 subtype. TLR3-L was administered in tumor-bearing mice. After 21 days, cells were isolated from the excised tumors and tumor-associated macrophages (TAMs) were assessed by flow cytometry for the expression of (A) CD80; (B) CD86; (C) TIM-3; and (D) MHC-II. The bar graphs expressed as mean ± SD represents the percentage change in the phenotypic markers on the F4/80⁺ positive cells (lower panel). The data shown are representative of two independent experiments (*p < 0.05; **p < 0.01; ***p < 0.001).

Administration of TLR-3L reverts the M2 phenotype of tumor-associated macrophages to M1 subtype. TLR3-L was administered in tumor-bearing mice. After 21 days, cells were isolated from the excised tumors and tumor-associated macrophages (TAMs) were assessed by flow cytometry for the expression of (A) CD80; (B) CD86; (C) TIM-3; and (D) MHC-II. The bar graphs expressed as mean ± SD represents the percentage change in the phenotypic markers on the F4/80⁺ positive cells (lower panel). The data shown are representative of two independent experiments (*p < 0.05; **p < 0.01; ***p < 0.001).