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. 2018 Jul 25;18:224. doi: 10.1186/s12906-018-2289-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effects of Phyllanthus amarus on the release of PGE₂ production (a). Effects of P. amarus on COX-2 protein expression (b) and mRNA expression (c). Data are presented as mean ± SEM with (n = 3). ^###P < 0.001 represents the significant difference from the control. *P < 0.05, **P < 0.01, and ***P < 0.001 represent significance to the LPS alone versus PA