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Effects of SB202190 (p38 inhibitor, 10 μM), U0126 (ERK inhibitor, 10 μM), SP600125 (JNK inhibitor, 10 μM), BAY 11–7082 (NF-κB inhibitor, 10 μM) and LY294002 (Akt inhibitor, 10 μM) on TNF-α production and COX-2 protein expression in LPS stimulated U937 macrophages. The values are expressed as the mean ± SEM with (n = 3). ###P < 0.001 indicates significant difference from the unstimulated control group. ***P < 0.001 indicate LPS versus LPS + inhibitors pretreatment
