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. 2018 Jul 26;16:115. doi: 10.1186/s12916-018-1104-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Flow diagram of the process to identify effective medications supported by high- or moderate-quality evidence. ^aStatistically significant at the p < 0.05 level. ^bEstimates were for subgroup estimates that did not meet our criteria for quality assessment. ^cSubgroup or sensitivity analysis as defined by authors. ^dPre-specified in the methods section of the review article. ^eUnique at the level of pharmacological subgroup in the World Health Organization’s Anatomical Therapeutic Chemical classification system. ^fUnique at the three-character coding level using the World Health Organization’s 10th revision of the International Statistical Classification of Diseases and Related Health Problems