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. 2018 Jul 25;37:170. doi: 10.1186/s13046-018-0843-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Enriched GO network groups using ClueGO/CluePedia-based enrichment. a Network view for KEGG pathway of CurcuUp-Regulated proteins and b Biological Process of CurcuDown-Regulated proteins. Terms (each represented as node) are functionally grouped based on shared genes (kappa score ≥ 0.4) and are shown with different colors. The specific players (proteins) of each node are highlighted with the respective gene name Node color represents the class that they belong. The size of the nodes indicates the degree of significance. Within each class, the most significant term (indicated with colored and bold characters) defines the name of the group. Ungrouped terms are not shown