Table 3.
Biological Pathway enrichment analysis of “metabolic” proteins down-regulated and up-regulated by curcumin
| Biological pathway | % of proteins | AdjP-Value (BH method) | Proteins |
|---|---|---|---|
| Curcu-Down-Regulated “metabolic” proteins | |||
| Metabolism | 29.82 | 2.04E-07 | TALDO1; ARG2; GSTP1; AHCY; TXN; FASN; TKT; COX6B1; GMPS; PAICS; HPRT1; CAD; ATIC; GSTO1; ACLY; GOT1; TK1; |
| Metabolism of carbohydrates | 14.04 | 2.04E-07 | TPI1; TALDO1; GPI; MDH1; PGK1; TKT; PGD; GOT1; |
| Gluconeogenesis | 8.77 | 1.19E-06 | TPI1; GPI; MDH1; PGK1; GOT1; |
| Glucose metabolism | 8.77 | 1.60E-05 | TPI1; GPI; MDH1; PGK1; GOT1; |
| Glycolysis | 5.26 | 5.13E-05 | TPI1; GPI; PGK1; |
| Cytosolic tRNA aminoacylation | 7.02 | 1.07E-04 | DARS; PPA1; VARS; YARS; |
| HIF-1-alpha transcription factor network | 7.02 | 4.28E-03 | ALDOA; PKM; LDHA; PGK1; |
| Pentose phosphate pathway (oxidative branch) | 3.51 | 4.78E-03 | G6PD; PGD; |
| Curcu-Up-Regulated “metabolic” proteins | |||
| Respiratory electron transport | 40.5 | 3.0E-24 | UQCRC1; CYC1; COX5B; NDUFS1; NDUFA5; NDUFB4; NDUFV1; UQCRH; NDUFA9; UQCRB; MT-ND5; NDUFB6; NDUFB5; NDUFB3; NDUFB9; |
| The citric acid (TCA) cycle and respiratory electron transport | 43.2 | 1.4E-23 | UQCRC1; CYC1; COX5B; NDUFS1; NDUFA5; NDUFB4; NDUFV1; UQCRH; NDUFA9; UQCRB; MT-ND5; NNT; NDUFB6; NDUFB5; NDUFB3; NDUFB9; |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | 40.5 | 1.9E-23 | UQCRC1; CYC1; COX5B; NDUFS1; NDUFA5; NDUFB4; NDUFV1; UQCRH; NDUFA9; UQCRB; MT-ND5; NDUFB6; NDUFB5; NDUFB3; NDUFB9; |
| Metabolism | 45.9 | 1.4E-11 | UQCRC1; CYC1; COX5B; NDUFS1; NDUFA5; NDUFB4; NDUFV1; CYP51A1; UQCRH; NDUFA9; UQCRB; MT-ND5; NNT; NDUFB6; NDUFB5; NDUFB3; NDUFB9; |
| Cholesterol biosynthesis | 8.1 | 1.5E-03 | FDFT1; CYP51A1; DHCR24; |