Table 1.
Meta-analyses on adjunctive therapy for neonatal sepsis.
| Intervention | Population | Outcome | RR (95% CI) | RCTs/infants | References |
|---|---|---|---|---|---|
| Pentoxifylline | All infants with confirmed or suspected sepsis | All-cause mortality to discharge | 0.57 (0.35–0.93) | 6/416 | (77) |
| All Infants with confirmed sepsis | All-cause mortality to discharge | 0.37 (0.19–0.73) | 4/235 | (77) | |
| Preterm infants with confirmed or suspected sepsis | All-cause mortality to discharge | 0.38 (0.20–0.71) | 4/277 | (77) | |
| IVIG (polyvalent or IgM-enriched) | All infants with suspected infection | All-cause mortality to discharge | 0.95 (0.80–1.13) | 9/2527 | (78) |
| IVIG (IgM-enriched) | All infants with suspected infection | All-cause mortality to discharge | 0.68 (0.39–1.20) | 4/267 | (78) |
| GM-CSF or G-CSF | All infants with confirmed or suspected sepsis | All-cause mortality to 14 days | 0.71 (0.38–1.33) | 7/257 | (79) |
| All infants with confirmed or suspected sepsis | All-cause mortality to discharge | 0.53 (0.25–1.16) | 5/178 | (79) | |
| Neutropenic infants with confirmed or suspected sepsis | All-cause mortality to discharge | 0.38 (0.16–0.95) | 3/97 | (79) | |
| Granulocyte transfusion | Neutropenic infants with confirmed or suspected sepsis | All-cause mortality to discharge | 0.89 (0.43–1.86) | 3/44 | (80) |
| Neutropenic preterm infants with confirmed or suspected sepsis | All-cause mortality to discharge | 0.94 (0.39–2.24) | 2/33 | (80) |
Cochrane reviews or the most updated meta-analysis on the topic were selected for inclusion in the table. Outcomes were selected based on relevance. Statistically significant results are marked in bold. CI, confidence interval; GM-CSF, granulocyte-macrophage colony stimulating factor; G-CSF, granulocyte colony stimulating factor; IVIG, intravenous immunoglobulin; RCT, randomized controlled trial; RR, risk ratio.