Table 5.
Target selection by applying TASC
| TASC item | I Localization |
II Expression pattern* ≠ |
III T/N ratio |
IV Upregulation in patients* (%) |
V In vivo imaging |
VI Enzymatic activity |
VII Internalization |
Score |
|---|---|---|---|---|---|---|---|---|
| Target | ||||||||
| EMA | Transmembrane | Diffuse | High | 100 | Yes [34, 49] | ND | ND | 20 |
| VEGF-α | Secreted | Diffuse | High | 100 | Yes [35, 36, 47] | ND | ND | 18 |
| PDGFR-β | Transmembrane | Diffuse | High | 100 | Yes [15] | ND | ND | 20 |
| SSTR-2 | Transmembrane | Diffuse | High | 100 | Yes [21, 23, 52] | Yes [46] | ND | 21 |
ND, not described; T/N ratio, tumour-to-normal tissue ratio
*Results based on this study
≠Expression patterns are considered “diffuse”, if moderate/diffuse or strong/diffuse staining is present in more than 66% of included cases