Table 2.
Hazard ratios for baseline demographic factors in the total and HLA-DQ2/8 cohort
| Total cohort (n = 23,187) | HLA-DQ2/8 cohort (n = 865) | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Maternal age | 1.00 | 0.97:1.0 | 0.88 | 1.02 | 0.97:1.1 | 0.48 |
| Sex | 0.77 | 0.56:1.1 | 0.10 | 0.80 | 0.48:1.3 | 0.39 |
| Gestational lengtha | 0.81 | 0.59:1.1 | 0.21 | 0.95 | 0.83:1.1 | 0.51 |
| Relative birth-weight quartile | 1.00 | 0.99:1.0 | 0.97 | 0.99 | 0.99:1.0 | 0.49 |
| Maternal education levelb | 0.84 | 0.65:1.07 | 0.16 | 0.89 | 0.59:1.4 | 0.59 |
| Paternal education levelb | 0.76 | 0.59:0.98 | 0.032 | 0.70 | 0.46:1.1 | 0.09 |
| Mother born in Sweden | 2.40 | 1.2:4.8 | 0.016 | 2.83 | 0.69:11 | 0.15 |
| Father born in Sweden | 2.97 | 1.3:6.7 | 0.009 | 1.21 | 0.44:3.4 | 0.71 |
| First-degree relative IDDMc | 6.98 | 4.3:11 | < 0.001 | 2.54 | 1.15:5.6 | 0.02 |
| HLA haplotype | ||||||
| DQ2/8 | 42.4 | 27:66 | < 0.001 | |||
| DQ8/8 or DQ8/X | 13.1 | 8.2:21 | < 0.001 | |||
| DQ2/2 or DQ2/X | 7.19 | 4.1:13 | < 0.001 | |||
| DQ X/X | Ref | Ref | Ref | |||
Ref reference level chosen in the analysis
aGestational week group (< 37, 37–40, > 40 weeks)
bEducation level: Primary school, high school, college, university
cFirst-degree relative with diabetes treated with insulin