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. 2018 Mar 24;41(4):1157–1171. doi: 10.1007/s10753-018-0763-1

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 7 — SERMs inhibit proliferation of PHA-activated primary T cells. Peripheral blood-derived mononuclear cells from five donors were cultured 3 days with phytohemagglutinin (PHA) and SERM or E2. Proliferation rate of non-adherent cells was measured with β-counter after 20 h ³H-thymidine incorporation. Selective estrogen receptor modulator stimulates IL-10 secretion from IFNγ+LPS-activated CD14-positive monocytes. Box extends from the 25th to 75th percentiles; line in the middle represents median, and whisker from min to max. Statistical significance was determined after one-way ANOVA followed by post hoc Holm-Sidak multiple comparison test. *P < 0.05; **P < 0.01; ***P < 0.001.