Table 4.
Mortality of systemic sclerosis 1994–2013 (per thousand person-years)
| Cases | Deaths | Years at risk | Crude mortality | Crude hazard ratios (95% CI) | Adjusted hazard ratios (95% CI) | P valuea | |
|---|---|---|---|---|---|---|---|
| Overall | 1327 | 302 | 6929 | 43.6 (38.9–48.8) | |||
| Sex | |||||||
| Male | 223 | 53 | 1119 | 47.4 (36.2–62.0) | 1 | 1 | P = 0.06 |
| Female | 1104 | 249 | 5810 | 42.9 (37.9–48.5) | 0.9 (0.7–1.2) | 0.7 (0.5–1.0) | |
| Age group (years) | |||||||
| Age 0–15 | 35 | 1 | 136 | 7.4 (1.0–52.2) | 1.2 (0.1–11.9) | 1.2 (0.1–11.4) | Ptrend < 0.0001 |
| Age 16–39 | 146 | 3 | 501 | 6.0 (1.9–18.6) | 1 | 1 | |
| Age 40–54 | 390 | 20 | 1572 | 12.7 (8.2–19.7) | 2.2 (0.6–7.3) | 1.2 (0.7–7.6) | |
| Age 55–69 | 668 | 89 | 2923 | 30.4 (24.7–37.5) | 5.4 (1.7–17.0) | 5.7 (1.8–17.9) | |
| Age 70–84 | 473 | 152 | 1616 | 94.1 (80.3–110.3) | 16.7 (5.3–52.3) | 17.7 (5.6–55.7) | |
| Age 85+ | 75 | 37 | 182 | 203.7 (147.6–281.2) | 36.2 (11.1–117.8) | 37.8 (11.6–123.2) | |
| IMD 2010b | |||||||
| Quintile 1 | 196 | 45 | 1048 | 42.9 (32.1–57.5) | 1 | 1 | Ptrend = 0.49 |
| Quintile 2 | 187 | 42 | 999 | 42.1 (31.1–56.9) | 1.0 (0.6–1.5) | 1.0 (0.7–1.6) | |
| Quintile 3 | 157 | 36 | 702 | 51.3 (37.0–71.1) | 1.2 (0.8–1.8) | 1.0 (0.6–1.5) | |
| Quintile 4 | 152 | 37 | 795 | 46.6 (33.7–64.3) | 1.1 (0.7–1.7) | 1.0 (0.7–1.6) | |
| Quintile 5 | 120 | 37 | 628 | 58.9 (42.7–81.3) | 1.3 (0.9–2.1) | 1.2 (0.8–1.9) | |
| IMD not known | 515 | 105 | 2758 | 38.1 (31.4–46.1) | 0.9 (0.6–1.3) | 0.9 (0.6–1.2) | |
Crude hazard ratio is calculated using univariable Cox regression, and adjusted hazard ratio is calculated using multi-variable Cox regression including sex, age group, and IMD-quintile as a priori confounders
aFrom multi-variable (adjusted) analysis, using the likelihood ratio test
bQuintile 1 is the most deprived, Quintile 5 is the least deprived