Table 2.
Discriminative ability for all-cause dementia
Prediction model | C-statistics at various follow-up horizons (95% CI) | |||
---|---|---|---|---|
2 years n/N = 63/6667 |
5 years n/N = 233/6667 |
10 years n/N = 515/6667 |
15 years n/N = 847/6667 |
|
CAIDE | 0.49 (0.42–0.56) | 0.54 (0.50–0.58) | 0.55 (0.53–0.58) | 0.55 (0.53–0.57) |
Age only | NA | NA | NA | NA |
Without age | 0.49 (0.42–0.56) | 0.54 (0.50–0.58) | 0.55 (0.53–0.58) | 0.55 (0.53–0.57) |
BDSI | 0.83 (0.75–0.90) | 0.80 (0.76–0.84) | 0.78 (0.76–0.81) | 0.76 (0.74–0.78) |
Age only | 0.83 (0.76–0.90) | 0.81 (0.78–0.85) | 0.81 (0.78–0.83) | 0.79 (0.77–0.81) |
Without age | 0.64 (0.57–0.71) | 0.63 (0.59–0.66) | 0.60 (0.58–0.63) | 0.59 (0.57–0.61) |
ANU-ADRI | 0.81 (0.77–0.86) | 0.78 (0.76–0.81) | 0.75 (0.74–0.77) | 0.70 (0.69–0.72) |
Age only | 0.83 (0.79–0.87) | 0.80 (0.77–0.82) | 0.77 (0.75–0.79) | 0.72 (0.71–0.74) |
Without age | 0.56 (0.49–0.64) | 0.51 (0.47–0.55) | 0.52 (0.49–0.54) | 0.51 (0.49–0.53) |
DRS | 0.84 (0.77–0.92) | 0.82 (0.78–0.86) | 0.81 (0.78–0.83) | 0.79 (0.77–0.81) |
Age only | 0.83 (0.76–0.90) | 0.81 (0.78–0.85) | 0.81 (0.78–0.83) | 0.79 (0.77–0.81) |
Without age | 0.63 (0.56–0.70) | 0.58 (0.54–0.62) | 0.57 (0.55–0.60) | 0.55 (0.53–0.57) |
CI confidence interval, n number of cases, N number of people at risk, CAIDE cardiovascular risk factors, aging, and dementia study, NA not applicable, BDSI brief dementia screening indicator, ANU-ADRI Australian National University Alzheimer’s Disease Risk Index and, DRS dementia risk score