Table 1.
Clinical characteristics of participants
| Variable | TDCOB | |||||
|---|---|---|---|---|---|---|
| Inter99 | TCOCT sample | Population-based control sample | ||||
| n | Median (interquartile range) | n | Median (interquartile range) | n | Median (interquartile range) | |
| Sex (male/female) | 2565/2690 | 306/383 | – | 266/409 | – | |
| Age (years) | 5255 | 45.1 (39.9–50.2) | 689 | 11.65 (9.7–13.9) | 675 | 12.54 (10.1–15.2) |
| Biochemical measures | ||||||
| HOMA-IR | 5063 | 1.36 (0.9–2.0) | 689 | 4.34 (2.8–6.4) | 675 | 2.23 (1.7–6.4) |
| Fasting serum insulin (pmol/l) | 5065 | 34 (23–50) | 689 | 115.00 (77.0–166.5) | 675 | 61.24 (45.5–83.9) |
| Fasting plasma glucose (mmol/l) | 5251 | 5.4 (5.1–5.8) | 689 | 5.10 (4.9–5.4) | 675 | 4.97 (4.8–5.2) |
| HbA1c (mmol/mol) | 5249 | 39.9 (36.6–43.2) | 686 | 34.00 (33.0–37.0) | 636 | 35.00 (33.0–36.0) |
| HbA1c (%) | 5249 | 5.8 (5.5–6.1) | 686 | 5.3 (5.2–5.5) | 636 | 5.4 (5.2–5.4) |
| Fasting plasma LDL-cholesterol (mmol/l) | 5186 | 3.42 (2.8–4.1) | 680 | 2.50 (2.1–3.0) | 635 | 2.10 (1.8–2.5) |
| Fasting plasma HDL-cholesterol (mmol/l) | 5247 | 1.40 (1.2–1.7) | 680 | 1.20 (1.0–1.4) | 635 | 1.50 (1.3–1.7) |
| Fasting plasma total cholesterol (mmol/l) | 5246 | 5.4 (4.8–6.2) | 680 | 4.20 (3.7–4.8) | 635 | 3.90 (3.6–4.5) |
| Fasting plasma triacylglycerol (mmol/l) | 5251 | 1.0 (0.8–1.5) | 680 | 0.90 (0.7–1.3) | 635 | 0.60 (0.5–0.9) |
| Anthropometrics | ||||||
| BMI (kg/m2) | 5253 | 25.39 (23.1–28.3) | NA | NA | NA | NA |
| BMI SDS | NA | NA | 689 | 2.92 (2.5–3.3) | 675 | 0.34 (−0.4–1.0) |
| WHR | 5252 | 0.85 (0.8–0.9) | 664 | 0.98 (0.9–1.0) | 672 | 0.83 (0.8–0.9) |
| BP | ||||||
| Systolic BP (mmHg) | 5254 | 130 (120–140) | NA | NA | NA | NA |
| Diastolic BP (mmHg) | 5253 | 80 (75–90) | NA | NA | NA | NA |
| Systolic BP SDS | NA | NA | 660 | 1.55 (0.8–2.6) | 642 | 1.57 (0.8–2.6) |
| Diastolic BP SDS | NA | NA | 660 | 0.59 (0.1–1.2) | 642 | 0.42 (−0.1–0.9) |
| DXA | ||||||
| Fat mass, total (%) | NA | NA | 391 | 43.96 (40.4–47.6) | 44 | 25.26 (22.2–31.5) |
| Fat mass, torso (%) | NA | NA | 391 | 45.18 (40.5–49.9) | 44 | 20.27 (16.9–28.5) |
| Fat mass, legs (%) | NA | NA | 391 | 45.63 (42.3–48.8) | 44 | 31.00 (27.5–36.6) |
| Fat mass, arms (%) | NA | NA | 391 | 46.02 (42.4–50.0) | 44 | 31.76 (24.9–36.4) |