Table 1.
Article | Model | US parameters | Result/conclusion |
---|---|---|---|
Tych et al. (2013) [10] | In vivo partial sciatic nerve ligation (pSNL) in Sprague-Dawley rats | 1.15-MHz pulses 0.2 s Responses at: pSNL: 176 ± 56 W/cm2 ISATA sham: 217 ± 25 W/cm2 ISATA normal: greater than 283 W/cm2 ISATA |
Neuropathic tissue is more sensitive to stimulation by intense focused ultrasound (iFU) than control tissue. |
McClintic et al. (2013) [11] | In vivo neuroma in paw of Sprague-Dawley rats | 2-MHz pulses 0.1 s Response at: Mechanical: 5.7 ± 2.2 g iFU: 343 ± 77 W/cm2 |
Successful stimulation of the neuroma by intense focused ultrasound required co-localization of the neuroma and intense focused ultrasound |
Wright et al. (2002) [14] | Distal interphalangeal joint of index finger of human | Experiment 1 4 pulses at 2 Hz 25 ms 50 ms 75 ms 100 ms Experiment 2 0.5 Hz, 1 Hz, 2 Hz, 3 Hz, 4 Hz, 5 Hz Constant pulse of 50 ms |
Experiment 1: “...a progressive decrease in pain thresholds was found with increased stimulus duration” Experiment 2: “Analysis of variance showed a significant interaction between tissue stimulated and pulse-train frequency.” |