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. 2018 Jul 10;22(9):60. doi: 10.1007/s11916-018-0711-7

Table 1.

Summaries of representative articles in section “Ultrasound for Peripheral Nerve Stimulation

Article Model US parameters Result/conclusion
Tych et al. (2013) [10] In vivo partial sciatic nerve ligation (pSNL) in Sprague-Dawley rats 1.15-MHz pulses
0.2 s
Responses at:
pSNL: 176 ± 56 W/cm2 ISATA
sham: 217 ± 25 W/cm2 ISATA
normal: greater than 283 W/cm2 ISATA
Neuropathic tissue is more sensitive to stimulation by intense focused ultrasound (iFU) than control tissue.
McClintic et al. (2013) [11] In vivo neuroma in paw of Sprague-Dawley rats 2-MHz pulses
0.1 s
Response at:
Mechanical: 5.7 ± 2.2 g
iFU: 343 ± 77 W/cm2
Successful stimulation of the neuroma by intense focused ultrasound required co-localization of the neuroma and intense focused ultrasound
Wright et al. (2002) [14] Distal interphalangeal joint of index finger of human Experiment 1
4 pulses at 2 Hz
25 ms
50 ms
75 ms
100 ms
Experiment 2
0.5 Hz, 1 Hz, 2 Hz, 3 Hz, 4 Hz, 5 Hz
Constant pulse of 50 ms
Experiment 1:
“...a progressive decrease in pain thresholds was found with increased stimulus duration”
Experiment 2:
“Analysis of variance showed a significant interaction between tissue stimulated and pulse-train frequency.”