Table 3.

Summaries of representative articles in sections “MRgHIFU Systems for Delivering High-Intensity Focused Ultrasound” and “Ablation of Peripheral Tissue by Ultrasound to Ameliorate Bone Pain Due To Cancer”

Article	Model	US parameters	Result/conclusion
Liberman et al. 2009 [33]	In vivo, bone metastases	- Avg. time: 66 min (range 22–162 min) - Avg. sonications: 17.3 (range 8–32)	- VAS score reduction - Edema at target area - No lasting damage, some calcification of target area
Hurwitz et al. 2016 [27]	In vivo, bone metastases	- Avg. sonication time: 83 ± 43 min - Max 65–85 °C	- NRS score reduction, p < 0.001
Napoli et al. 2017 [29]	In vivo, human Osteoid osteomas	- 4 ± 1.8 sonications	- VAS score reduction (p = 0.001) - 27/29 patients had pain absence and no intake of NSAIDs
Li et a. 2010 [30]	In vivo, human Osteosarcoma, malignant fibrous histiocytoma	- 70 to 169 W/cm2 - Scanning speed = 1–3 mm/s - Avg. sessions = 2.29 h	- Pain reduction of p < 0.05 - PET-CT revealed no abnormal radioactivity concentration in tumor areas.