Table 4.
Summaries of representative articles in section “Ablation of the Brain to Treat Pain”
| Article | Model | US parameters | Result/conclusion |
|---|---|---|---|
| Magara et al. 2012 [41] | In vivo, human Pallidothalamic tract |
710 kHz Mean application time: 13 s (range 10–21) Peak temp: 52–59 °C |
Group 1: avg. lesion of 83 mm3 with disappearance at 3 months Group 2: avg. lesion of 172 mm3 with maintained visualization at 3 months |
| Chazen et al. 2017 [43] | In vivo, human Thalamotomy |
650 kHz mean application time: 10–20 s Peak temp: 55–62 °C |
Reduction in contralateral intention tremor |
| Chang et al. 2014 [39] | In vivo, human Thalamotomy |
650 kHz Mean application time: 10–20s Peak temp: 55–62 °C |
Immediate and sustained improvements in tremors Lesion of thalamic nucleus |
| Martin et al. 2009 [44] | In vivo, human Central lateral thalamotomy (CLT) |
650 kHz Mean application time: 10–20 s Peak temp: 53–60 °C |
3–5-mm lesion in 48-h post-op MRI Long-term (~ 3.75 years) pain relief between 50 and 100% in 53% of patients |
| Jeanmonod et al. 2012 [45] | In vivo, human Central lateral thalamotomy (CLT) |
650 kHz Mean application time: 10–20 s Peak temp: 51–64 °C |
Lesions of 3–4 mm (d) Mean post-op VAS score reduction of 42.3 and 40.7% at 3 months and 1 year respectively |