Table 1.
Bivariate analysis between patients treated (fibrinolytic therapy group) and not treated (control group) with rt-PA
| Fibrinolytic therapy n = 577 | Control n = 577 | P | |
|---|---|---|---|
| Age, years | 71.7 ± 12.2 | 70.7 ± 13.4 | 0.062 |
| Men, % | 50.4 | 55.3 | 0.111 |
| Previous mRS | 0 [0, 1] | 0 [0, 1] | 0.054 |
| History of high blood pressure, % | 62.4 | 60.7 | 0.586 |
| History of diabetes, % | 19.4 | 23.7 | 0.086 |
| History of alcoholism, % | 8.7 | 11.3 | 0.169 |
| History of smoking, % | 13.9 | 15.6 | 0.455 |
| History of dyslipidemia, % | 40.2 | 40.4 | 1.000 |
| Peripheral arterial disease, % | 7.1 | 5.7 | 0.400 |
| Ischemic heart disease, % | 11.8 | 11.4 | 0.927 |
| Atrial fibrillation, % | 21.3 | 22.7 | 0.619 |
| Known carotid disease, % | 1.2 | 0.9 | 0.773 |
| Previous TIAs, % | 1.9 | 0.9 | 0.207 |
| OSCP | < 0.0001 | ||
| TACI, % | 45.1 | 28.8 | |
| PACI, % | 48.5 | 49.4 | |
| POCI, % | 6.4 | 21.8 | |
| NIHSS at admission | 14 [10, 18] | 9 [6, 16] | < 0.0001 |
| NIHSS at 24 h | 8 [5, 16] | 8 [6, 15] | 0.237 |
| ≥ 8 points of the NIHSS in the first 24 h, % | 24.8 | 2.6 | < 0.0001 |
| Start-inclusion time, min | 175.6 ± 40.6 | 239.9 ± 69.1 | < 0.0001 |
| Start-needle time, min | 224.1 ± 39.6 | – | |
| TOAST | 0.458 | ||
| Large vessel disease, % | 33.4 | 30.7 | |
| Cardioembolic, % | 39.2 | 39.0 | |
| Indeterminate, % | 27.4 | 30.3 | |
| Hemorrhagic transformation | < 0.0001 | ||
| Asymptomatic, % | 5.7 | 1.4 | |
| Symptomatic, % | 1.9 | 0.9 | |
| mRS at discharge | 4 [2, 5] | 4 [2, 5] | 0.964 |
| mRS at 3 months | 2 [1, 4] | 4 [3, 6] | < 0.0001 |
| Good outcome at 3 months, % | 53.8 | 24.1 | < 0.0001 |
| Axillary temperature at admission, °C (n = 1154) | 36.3 ± 0.6 | 36.3 ± 0.5 | 0.926 |
| Blood glucose at admission, mg/dL (n = 1154) | 135.7 ± 50.4 | 139.9 ± 61.5 | 0.199 |
| Leukocytes at admission, ×103/mmc (n = 1154) | 9.1 ± 3.4 | 9.1 ± 3.1 | 0.926 |
| Fibrinogen at admission, mg/dL (n = 926) | 416.6 ± 116.1 | 425.9 ± 88.8 | 0.176 |
| C-reactive protein at admission, mg/dL (n = 894) | 3.9 ± 4.8 | 3.6 ± 3.6 | 0.249 |
| Sedimentation rate at admission, mm/h (n = 999) | 22.2 ± 22.4 | 24.1 ± 21.2 | 0.187 |
| Albuminuria, mg/g of creatinine (n = 785) | 7.1 ± 33.2 | 4.4 ± 26.3 | 0.199 |