Table 2.
Bivariate analysis between the group of patients with and without functional outcome worsening (mRS from discharge to 3 months < 0)
| No n = 914 | Yes n = 240 | P | |
|---|---|---|---|
| Age, years | 70.9 ± 12.1 | 72.3 ± 11.8 | 0.131 |
| Men, % | 53.5 | 50.4 | 0.424 |
| Previous mRS | 0 [0, 1] | 0 [0, 1] | 0.307 |
| History of high blood pressure, % | 62.6 | 57.5 | 0.157 |
| History of diabetes, % | 21.0 | 23.8 | 0.378 |
| History of alcoholism, % | 9.0 | 13.8 | 0.039 |
| History of smoking, % | 16.2 | 9.2 | 0.006 |
| History of dyslipidemia, % | 39.1 | 45.0 | 0.104 |
| Peripheral arterial disease, % | 6.2 | 7.1 | 0.657 |
| Ischemic heart disease, % | 11.1 | 13.8 | 0.258 |
| Atrial fibrillation, % | 23.2 | 17.5 | 0.066 |
| Known carotid disease, % | 1.2 | 0.4 | 0.478 |
| Previous TIAs, % | 1.5 | 0.8 | 0.546 |
| OSCP | 0.094 | ||
| TACI, % | 37.3 | 35.4 | |
| PACI, % | 47.2 | 55.8 | |
| POCI, % | 15.5 | 8.8 | |
| NIHSS at admission | 12 [8, 17] | 11 [7, 16] | 0.062 |
| NIHSS at 24 h | 8 [5, 15] | 10 [6, 16] | 0.071 |
| ≥ 8 points of NIHSS in the first 24 h, % | 16.5 | 2.9 | < 0.0001 |
| Start-inclusion time, min | 198.7 ± 57.9 | 210.1 ± 66.7 | 0.016 |
| Start-needle time, min (n = 577) | 221.5 ± 39.6 | 230.2 ± 39.3 | 0.017 |
| TOAST | 0.535 | ||
| Large vessel disease, % | 31.3 | 35.0 | |
| Cardioembolic, % | 39.4 | 37.9 | |
| Indeterminate, % | 29.3 | 27.1 | |
| rt-PA treatment, % (n = 577) | 43.9 | 73.3 | < 0.0001 |
| Hemorrhagic transformation | 0.899 | ||
| Asymptomatic, % | 3.6 | 3.3 | |
| Symptomatic, % | 1.3 | 1.7 | |
| mRS at discharge | 4 [2, 5] | 3 [2, 4] | < 0.0001 |
| mRS at 3 months | 3 [1, 5] | 4 [3, 5] | < 0.0001 |
| Good outcome at 3 months, % | 40.6 | 18.3 | < 0.0001 |
| Axillary temperature at admission, °C (n = 1154) | 36.3 ± 0.6 | 36.4 ± 0.6 | 0.206 |
| Blood glucose at admission, mg/dL (n = 1154) | 136.8 ± 54.9 | 141.8 ± 61.0 | 0.217 |
| Leukocytes at admission, ×103/mmc (n = 1154) | 8.9 ± 3.2 | 9.2 ± 3.2 | 0.360 |
| Fibrinogen at admission, mg/dL (n = 926) | 420.5 ± 100.1 | 422.2 ± 119.7 | 0.831 |
| C-reactive protein at admission, mg/dL (n = 894) | 3.7 ± 4.2 | 4.1 ± 4.9 | 0.227 |
| Sedimentation rate at admission, mm/h (n = 999) | 22.8 ± 21.3 | 24.0 ± 23.9 | 0.464 |
| Albuminuria, mg/g of creatinine(n = 785) | 5.6 ± 30.0 | 6.7 ± 30.7 | 0.680 |