Polypharmacy is an urgent issue that requires a co-ordinated global effort to provide medical care systems that better serve patients with multimorbidity.

This transition requires a shift in medical education, research, and diagnostic frameworks, and reexamination of the measures used as quality indicators.

This position statement from the International Group for Reducing Inappropriate Medication Use & Polypharmacy briefly summarizes the current situation and provides a call to action for moving forward, proposing 10 recommendations for action and 12 recommendations for research.