Table 2.
Sensitivity/specificity and logistic regression analyses
| Group | Predictor | UF (L) | Cutoff | SN/SP (%) | AUC | P-value* | P-log** |
|---|---|---|---|---|---|---|---|
| Entire cohort (n=244) | IVC CI (%) | ≥0.5 | <23.0 | 70 | 0.72±0.04 | <0.001 | <0.001 |
| ≥1.0 | <20.9 | 65 | 0.71±0.04 | <0.001 | <0.001 | ||
| ≥1.5 | <19.6 | 63 | 0.68±0.04 | <0.001 | <0.001 | ||
| ≥2.0 | <18.5 | 58 | 0.62±0.04 | <0.001 | 0.003 | ||
| Entire cohort (n=244) | IVCmax (cm) | ≥0.5 | >1.97 | 60 | 0.66±0.04 | <0.001 | <0.001 |
| ≥1.0 | >2.02 | 57 | 0.64±0.04 | <0.001 | <0.001 | ||
| ≥1.5 | >2.03 | 59 | 0.64±0.04 | <0.001 | <0.001 | ||
| ≥2.0 | >2.05 | 59 | 0.64±0.04 | <0.001 | <0.001 | ||
| Entire cohort (n=244) | IVCmin (cm) | ≥0.5 | >1.49 | 66 | 0.72±0.04 | <0.001 | <0.001 |
| ≥1.0 | >1.55 | 63 | 0.70±0.04 | <0.001 | <0.001 | ||
| ≥1.5 | >1.62 | 63 | 0.67±0.04 | <0.001 | <0.001 | ||
| ≥2.0 | >1.65 | 60 | 0.64±0.04 | <0.001 | <0.001 | ||
| Entire cohort (n=116) | Mean CVP (cm H2O) | ≥0.5 | >9.58 | 55 | 0.55±0.06 | 0.212 | 0.936 |
| ≥1.0 | >9.74 | 54 | 0.53±0.06 | 0.300 | 0.745 | ||
| ≥1.5 | >9.68 | 57 | 0.56±0.06 | 0.155 | 0.908 | ||
| ≥2.0 | >9.94 | 53 | 0.48±0.05 | 0.380 | 0.298 | ||
| Entire cohort (n=21) | Mean PAOP (mmHg) | ≥0.5 | >19.5 | 50 | 0.59±0.14 | 0.272 | 0.450 |
| ≥1.0 | >19.5 | 50 | 0.59±0.14 | 0.272 | 0.450 | ||
| ≥1.5 | >20.4 | 39 | 0.45±0.14 | 0.370 | 0.811 | ||
| ≥2.0 | >19.9 | 36 | 0.37±0.13 | 0.147 | 0.240 | ||
| Entire cohort (n=23) | Cardiac output (L/min) | ≥0.5 | <5.24 | 56 | 0.58±0.12 | 0.266 | 0.975 |
| ≥1.0 | <5.24 | 56 | 0.58±0.12 | 0.266 | 0.975 | ||
| ≥1.5 | <5.16 | 50 | 0.38±0.13 | 0.187 | 0.278 | ||
| ≥2.0 | <5.17 | 62 | 0.62±0.13 | 0.348 | 0.843 | ||
| Ventilated (n=145) | IVC CI (%) | ≥0.5 | <22.0 | 71 | 0.70±0.07 | 0.002 | <0.001 |
| ≥1.0 | <20.3 | 65 | 0.70±0.06 | <0.001 | <0.001 | ||
| ≥1.5 | <16.9 | 59 | 0.68±0.05 | <0.001 | <0.001 | ||
| ≥2.0 | <16.5 | 56 | 0.59±0.05 | 0.030 | 0.033 | ||
| Non-ventilated (n=99) | IVC CI (%) | ≥0.5 | <24.0 | 69 | 0.72±0.06 | <0.001 | 0.009 |
| ≥1.0 | <22.1 | 65 | 0.71±0.05 | <0.001 | 0.004 | ||
| ≥1.5 | <20.3 | 59 | 0.67±0.05 | <0.001 | 0.015 | ||
| ≥2.0 | <20.3 | 57 | 0.64±0.06 | 0.008 | 0.058 | ||
| Vasopressors (n=73) | IVC CI (%) | ≥0.5 | <20.5 | 69 | 0.73±0.07 | 0.001 | 0.025 |
| ≥1.0 | <18.4 | 66 | 0.71±0.07 | 0.001 | 0.022 | ||
| ≥1.5 | <17.2 | 72 | 0.78±0.06 | <0.001 | <0.001 | ||
| ≥2.0 | <13.7 | 65 | 0.66±0.07 | 0.008 | 0.024 | ||
| No vasopressors (n=171) | IVC CI (%) | ≥0.5 | <23.9 | 69 | 0.72±0.05 | <0.001 | <0.001 |
| ≥1.0 | <21.8 | 65 | 0.70±0.05 | <0.001 | <0.001 | ||
| ≥1.5 | <20.1 | 59 | 0.64±0.04 | <0.001 | 0.001 | ||
| ≥2.0 | <19.8 | 58 | 0.60±0.04 | 0.013 | 0.018 | ||
| ESRD (n=67) | IVC CI (%) | ≥0.5 | <20.7 | 65 | 0.77±0.08 | <0.001 | 0.008 |
| ≥1.0 | <18.4 | 54 | 0.62±0.08 | 0.062 | 0.099 | ||
| ≥1.5 | <18.1 | 55 | 0.59±0.07 | 0.099 | 0.285 | ||
| ≥2.0 | <17.3 | 56 | 0.57±0.07 | 0.166 | 0.496 | ||
| AKI (n=130) | IVC CI (%) | ≥0.5 | <22.2 | 65 | 0.64±0.07 | 0.017 | 0.111 |
| ≥1.0 | <22.1 | 68 | 0.69±0.06 | <0.001 | 0.007 | ||
| ≥1.5 | <20.2 | 61 | 0.66±0.05 | <0.001 | 0.008 | ||
| ≥2.0 | <19.6 | 58 | 0.58±0.05 | 0.054 | 0.115 | ||
| AKI/CKD (n=47) | IVC CI (%) | ≥0.5 | <23.8 | 86 | 0.87±0.06 | <0.001 | 0.001 |
| ≥1.0 | <21.9 | 82 | 0.85±0.06 | <0.001 | 0.001 | ||
| ≥1.5 | <20.1 | 76 | 0.85±0.06 | <0.001 | 0.002 | ||
| ≥2.0 | <17.7 | 67 | 0.74±0.08 | 0.001 | <0.001 | ||
| Patients with more than one encounter: first encounter (n=43) | IVC CI (%) | ≥0.5 | <26.2 | 74 | 0.79±0.07 | <0.001 | 0.041 |
| ≥1.0 | <25.2 | 75 | 0.74±0.08 | 0.002 | 0.084 | ||
| ≥1.5 | <22.4 | 75 | 0.75±0.08 | <0.001 | 0.033 | ||
| ≥2.0 | <20.9 | 60 | 0.60±0.09 | 0.125 | 0.267 | ||
| Patients with more than one encounter: second encounter (n=43) | IVC CI (%) | ≥0.5 | <28.8 | 76 | 0.82±0.10 | <0.001 | 0.010 |
| ≥1.0 | <23.7 | 65 | 0.70±0.10 | 0.020 | 0.042 | ||
| ≥1.5 | <20.4 | 63 | 0.68±0.08 | 0.012 | 0.107 | ||
| ≥2.0 | <20.3 | 56 | 0.59±0.09 | 0.152 | 0.320 |
Notes: The cutoff was chosen at the point where sensitivity equals specificity.
P-value <0.05 indicates that the area under the ROC is significantly >0.5 and that there is a relationship between the variable and whether a specific UF volume was removed or not.
P-value <0.05 indicates that the variable is a significant predictor by logistic regression of whether a specific UF volume was removed or not.
Abbreviations: AKI, acute kidney injury; AUC, area under the ROC curve; CI, collapsibility index; CKD, chronic kidney disease; CVP, central venous pressure; ESRD, end-stage renal disease; IVC, inferior vena cava; n, number of encounters; PAOP, mean pulmonary artery occlusion pressure; ROC, receiver operating characteristic; SN, sensitivity; SP, specificity; UF, ultrafiltration.