Features and properties of andexanet alfa [coagulation factor Xa (recombinant), inactivated-zhzo]

Alternative names	AndexXa; AnXa; IndexXa; PRT-064445; PRT-4445; PRT-44545; recombinant factor-Xa-Portola; rfXa-inhibitor-antidote
Class	Antidotes; antihaemorrhagics; disulfides; recombinant proteins
Mechanism of action	Modified factor Xa recombinant protein; blood coagulation stimulants
Route of administration	Intravenous
Pharmacodynamics	Binds to factor Xa inhibitors with high affinity and reverses the anticoagulant activity
Pharmacokinetics	Dose-proportional pharmacokinetics; mean apparent volume of distribution ≈ 5 L; mean elimination half-life 5–7 h
Most frequent adverse events	Urinary tract infections, pneumonia
ATC codes
WHO ATC code	B02 (antihemorrhagics)
EphMRA ATC code	B2B (antagonists (antidotes to anticoagulants))
Chemical name	des-(6-39)-Human blood-coagulation factor X light chain (98–108′)-disulfide with [185′-alanine (S > A)] human activated factor Xa heavy chain