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FE-SEM photographs of pure (A) and the SEDS process-assisted nanoparticulate forms (B) of methotrexate powder.
Note: Reprinted from J Supercrit Fluids. Vol 67. Chen AZ, Li L, Wang SB, et al. Nanonization of methotrexate by solution-enhanced dispersion by supercritical CO2. Pages 7–13. Copyright 2012, with permission from Elsevier.59
Abbreviations: FE-SEM, field emission-scanning electron microscopy; SEDS, solution-enhanced dispersion by supercritical fluids.
