Fig. 3.

Disability outcome measures used in phase III progressive MS trials (n = 18): a EDSS-related measures; b other outcome measures. Includes unpublished trials and trials published from 1997 onwards; note that in some trials, endpoints relating to the same measure were included as both primary and secondary endpoints (e.g. time to 3-month worsening of EDSS and the proportion of patients with 3-month worsening of EDSS). AUC area under the curve, CGI-I Clinical Global Impression of Improvement, EDSS Expanded Disability Status Scale, MSFC Multiple Sclerosis Functional Composite, MS multiple sclerosis, PGI-I Patient Global Impression of Improvement, RFSS Regional Functional System Score, SF-36 Medical Outcomes Study Short-Form (36-item) Health Survey, SNRS Scripps Neurologic Rating Scale