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. 2018 Jun 20;32(6):543–558. doi: 10.1007/s40263-018-0530-8

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Disability outcome measures used over time in phase III progressive MS trials published since 2007 (n = 18): a EDSS-related measures; b other outcome measures. Published trials only (trials could not be assessed according to start date, as this was not available for all published trials). EDSS Expanded Disability Status Scale, MS multiple sclerosis, MSFC Multiple Sclerosis Functional Composite, RFSS Regional Functional Scoring Scale, SF–36 Medical Outcomes Study Short-Form (36-item) Health Survey, SNRS Scripps Neurologic Rating Scale